๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

The treatment of postmenopausal women with advanced breast cancer with buserelin

โœ Scribed by J. H. Waxman; S. J. Harland; R. C. Coombes; P. F. M. Wrigley; J. S. Malpas; T. Powles; T. A. Lister

Publisher
Springer
Year
1985
Tongue
English
Weight
239 KB
Volume
15
Category
Article
ISSN
0344-5704

No coin nor oath required. For personal study only.

โœฆ Synopsis

Repeated administration of long-acting analogues of gonadotrophin-releasing hormone down-regulates the pituitary gonadotrophins and gonadal hormones. The activity of these compounds in premenopausal women with breast cancer has been previously noted. In an attempt to cause a highly selective medical hypophysectomy 18 consecutive postmenopausal women with symptomatic advanced breast cancer were treated with intranasal buserelin in divided dosages of either 600 or 1000 micrograms daily. The pituitary gonadotrophins were suppressed in all patients, without objective evidence of response. This is in contrast with an earlier finding that the long-acting analogues of gonadotrophin-releasing hormone were effective in postmenopausal patients with breast cancer.

๐Ÿ“œ SIMILAR VOLUMES

Use of aromatase inhibitors in postmenop
Use of aromatase inhibitors in postmenopausal women with advanced breast cancer
โœ Roseman, Barry J.; Buzdar, Aman U.; Singletary, S. Eva ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 39 KB ๐Ÿ‘ 2 views

Surgeons have been involved in the management of metastatic breast cancer since the technique of ovarian ablation was introduced in 1896. However, as newer hormonal and chemotherapeutic regimens were developed, drug therapy gradually replaced surgery as the preferred treatment for metastatic breast