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The treatment of poor prognosis myelomatosis with a cytosine arabinoside containing combination

✍ Scribed by D. J. Dodwell; I. G. McGill

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 92 KB
Volume: 7
Category: Article
ISSN: 0278-0232
DOI: 10.1002/hon.2900070406

No coin nor oath required. For personal study only.

✦ Synopsis

During the last 14 years a combination of cytosine arabinoside, vincristine, cyclophosphamide and prednisolone (ARA-COP) has been evaluated in 37 consecutive patients (M:F 25: 12) presenting with stage 3A (1 1) or stage 3B (26) multiple myeloma according to the staging system of Dune and Salmon (1975).

Of these patients (age 42-84, median 62) 27 had corrected Caf+ > 3.0 mM, 3 1 had multiple lytic lesions, 17 had Hb. < 8.5 g/100 ml and 12 had a Karnofsky performance index < 50 (median 50).

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