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The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF

✍ Scribed by Hiroko Shibata; Yasuo Yoshioka; Yasuhiro Abe; Akiko Ohkawa; Tetsuya Nomura; Kyoko Minowa; Yohei Mukai; Shinsaku Nakagawa; Madoka Taniai; Tsunetaka Ohta; Haruhiko Kamada; Shin-ichi Tsunoda; Yasuo Tsutsumi


Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
823 KB
Volume
30
Category
Article
ISSN
0142-9612

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✍ Joyce Van Meurs; Peter Van Lent; Reinout Stoop; Astrid Holthuysen; Irwin Singer; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 545 KB

Objective. The destruction of articular cartilage during arthritis is due to proteolytic cleavage of the extracellular matrix components. This study investigates the kinetic involvement of metalloproteinases (MMPs) in the degradation of the 2 major cartilage components, aggrecan and type II collagen