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The Transport of Leucine and Aminocyclopentanecarboxylate Across the Intact, Energy-Depleted Rat Blood-Brain Barrier

✍ Scribed by Greenwood, J.; Hazell, A. S.; Pratt, O. E.


Book ID
118675623
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
354 KB
Volume
9
Category
Article
ISSN
0271-678X

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## Abstract In adult rats, using the single‐pass brain uptake technique with a tritiated water standard, L‐phenylalanine was shown to enter brain across the blood‐brain barrier (BBB) by both a saturable and diffusionary process. A kinetic analysis of the data revealed Michaelis constant (K~a~) of 0