𝔖 Bobbio Scriptorium
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The transport of L-6-fluorodopa and its metabolites from blood to cerebrospinal fluid and brain

✍ Scribed by Dr. John P. Hammerstad; Brian D. Pate; Kellie A. Hewitt; Grace L-Y. Chan; Thomas J. Ruth; Donald B. Calne


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
617 KB
Volume
34
Category
Article
ISSN
0364-5134

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The objective of this study was to establish the optimal blood concentrations of the potent P-glycoprotein (P-gp) inhibitor GF120918 (Elacridar) required to achieve maximal knockout of this efflux transporter in the blood-brain barrier (BBB) of mice, rats, and guinea pigs. Genetic mdr1a/b(-/-) knock