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The Transmembrane Domain of the Oncogenic Mutant ErbB-2 Receptor: A Structure Obtained from Site-specific Infrared Dichroism and Molecular Dynamics

✍ Scribed by Andrew J. Beevers; Andreas Kukol


Book ID
116663171
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
518 KB
Volume
361
Category
Article
ISSN
0022-2836

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✍ Norbert Garnier; Daniel Genest; Jean Pierre Duneau; Monique Genest 📂 Article 📅 1997 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 210 KB 👁 2 views

Dimerization models of c-erbB2 transmembrane domains (Leu651-Ile675) are studied by molecular mechanics and molecular dynamics simulations. Both wild and Glu mutated transmembrane helices exhibit the same relative orientation for favorable associations and dimerize preferentially in left-handed coil