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The transition from hyperplasia to invasive carcinoma of the breast

โœ Scribed by Lakhani, Sunil R.

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
284 KB
Volume
187
Category
Article
ISSN
0022-3417

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โœฆ Synopsis

The multistep model of carcinogenesis in the breast suggests a transition from normal epithelium to invasive carcinoma via non-atypical and atypical hyperplasia and in situ carcinoma. Within the breast, these proliferations are heterogeneous in their cytological and architectural characteristics. This review considers the evidence supporting a precursor role for these preinvasive lesions.

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## BACKGROUND. Histologic grade is well recognized for its prognostic significance in cases of primary operable invasive breast carcinoma; however, the majority of studies in which grade has been assessed have been based on single-center trials. In addition, the role of grade in predicting respon