The transglutaminase, Factor XIIIA, is present in articular chondrocytes
β Scribed by A.K. Rosenthal; I. Masuda; C.M. Gohr; B.A. Derfus; M. Le
- Book ID
- 114476274
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 391 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1063-4584
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The affinities of Factor XIII (FXIII), Factor XIIIa (FXIIIa), and cellular transglutaminase (Tg) for fibrinogen (Fgn), fibrin (Fbn), and fibronectin (Fn) were compared using a solid-phase binding assay. Initial rates of binding were as follows: FXIII bound Fbn 3-fold more than Fgn. FXIII did not bin
## Abstract ## Objective To uncover the mechanism by which hypoxia enhances cartilage matrix synthesis by human articular chondrocytes. ## Methods The hypoxic response was investigated by exposing normal (nonarthritic) human articular chondrocyte cultures to 20% oxygen and 1% oxygen. Induction o