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The transgenic Tg.AC mouse model for identification of chemical carcinogens

✍ Scribed by Raymond W Tennant; Raymond R Tice; Judson W Spalding

Book ID
119539694
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
80 KB
Volume
102-103
Category
Article
ISSN
0378-4274

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## Abstract The Tg.AC transgenic mouse carries a v‐Ha‐__ras__ transgene. Skin papillomas develop in Tg.AC mice upon repeated dermal application of tumor promoters and carcinogens. The transgene is inserted at a single site on chromosome 11 in a multiple‐copy array. Although most of the β‰₯ 40 copies