The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
β Scribed by Wei-ping Zheng; Richard A Flavell
- Book ID
- 117267238
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 248 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0092-8674
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GATA-3 is a zinc-finger transcription factor that is essential for both early T cell development and Th2 cell differentiation. To quantify GATA-3 expression during T cell development in vivo in the mouse, the GATA-3 gene was targeted by insertion of a lacZ reporter by homologous recombination in emb
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