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The transcription factor FoxO1 is required in endothelial cells for vascular remodeling of the mouse yolk sac

✍ Scribed by Monica D. Garcia; Tiffany M. Sills; Ryan S. Udan; Tegy J. Vadakkan; Ronald A. DePinho; Karen K. Hirschi; Mary E. Dickinson


Book ID
113955144
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
50 KB
Volume
356
Category
Article
ISSN
0012-1606

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## Abstract Transcription factor Ets‐1 is induced in endothelial cells (ECs) by angiogenic factors, and promotes angiogenesis by inducing angiogenesis‐related genes such as MMPs and integrin Ξ²3. Here, we examined the effect of Ets‐1 on apoptosis in ECs. Overexpression of Ets‐1 in human umbilical ve