The traceless Staudinger ligation with fluorine-18: a novel and versatile labeling technique for the synthesis of PET-radiotracers

✍ Scribed by Marc Pretze; Frank Wuest; Tim Peppel; Martin Köckerling; Constantin Mamat

• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 511 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.09.134

✦ Synopsis

The development of rapid radiolabeling techniques under mild reaction conditions involving the shortlived positron emitter fluorine-18 remains a special challenge in organic PET chemistry. This work describes a novel and facile application of the traceless Staudinger ligation as a mild and versatile labeling method for preparation of various radiotracers labeled with fluorine-18.