The toxicity of 1-amino-3-chloro-2-propanol hydrochloride (CL88,236) in the rhesus monkey
โ Scribed by R. Heywood; R.J. Sortwell; D.E. Prentice
- Book ID
- 103656686
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 758 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0300-483X
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The antihypertensive drug, l-[(l-methylethyl)arnino]-3- hydrochloride has been labeled with carbon-14 in the 1-position of the naphthalene. A total of 18.76 mCi was prepared in five steps starting with l-naphtholl-%. The overall yield for the synthesis was 3 3 . 6 % following five recrystallizatio
(R)- and (S)-1-chloro-3-(1-naphthyloxy)-2-propanol are intermediates in the synthesis of beta-adrenergic blocking agents and antihypertensive drugs such as propranolol and nadoxolol. Herein, improvement in the preparation of racemic 1-chloro-3-(1-naphthyloxy)-2-propanol generated from 1-naphthol and