The toxic oil syndrome: An example of an exogenously induced autoimmune reaction

✍ Scribed by Susanne A. Bell

• Book ID: 104735145
• Publisher: Springer
• Year: 1996
• Tongue: English
• Weight: 223 KB
• Volume: 23
• Category: Article
• ISSN: 0301-4851
• DOI: 10.1007/bf00351178

✦ Synopsis

The toxic oil syndrome (TOS) is a chemically induced autoimmune-like reaction in humans. The etiologic agent(s) have so far not clearly been identified. A short overview is given on this disease which is associated with a unique antibody specificity to cryptic epitopes of C-reactive protein in affected patients. In addition a murine model for TOS is described which suggests that genetic susceptibility might play a role in inducing a similar syndrome in mice. These differences are reflected in the immunological alterations and cytokine production caused by the toxicant.