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The total synthesis of (±)-arisugacin A

✍ Scribed by Kevin P. Cole; Richard P. Hsung; Xiao-Fang Yang

Book ID
104250970
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
142 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

A 20-step total synthesis of (±)-arisugacin A with an overall yield of 2.1% is described here. This synthesis features highly convergent formal [3+3] cycloaddition and a strategic dihydroxylation-deoxygenation protocol leading to the desired angular C12a-OH.

📜 SIMILAR VOLUMES

The Total Synthesis of (.+-.)-Arisugacin
The Total Synthesis of (.+-.)-Arisugacin A (I).
✍ Richard P. Hsung; Kevin P. Cole; Luke R. Zehnder; Jiashi Wang; Lin-Li Wei; Xiao- 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 74 KB 👁 2 views
ChemInform Abstract: The Total Synthesis
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✍ Kevin P. Cole; Richard P. Hsung; Xiao-Fang Yang 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 24 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

The first enantioselective total synthes
The first enantioselective total synthesis of (−)-arisugacin A
✍ Kevin P. Cole; Richard P. Hsung 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 108 KB

The first enantioselective synthesis of (-)-arisugacin A in 17 steps is described here, featuring a CBS asymmetric ketone reduction and a highly stereoselective formal [3+3] cycloaddition approach. This concise synthesis of the enantiomer unambiguously confirms the original assignment of the absolut