The ToI-β transgenic mouse: a model to study the specific role of NF-κB in β-cells
✍ Scribed by Roy Eldor; Ketty Baum; Roy Abel; Dror Sever; Danielle Melloul
- Book ID
- 117371198
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 931 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0168-8227
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## Abstract IL‐1β is an important mediator in the pathogenesis of type 1 diabetes both in vivo and in vitro and it has been shown to induce islet β‐cell apoptosis. Most of the IL‐1β effects seem to be mediated by NF‐κB transcription factor activation, but its role in the induction of islet β‐cell a
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