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The thrills and agonies of using next-generation sequencing for somatic mutation detection in cancer

โœ Scribed by Tsongalis, Gregory J


Book ID
127328982
Publisher
Future Medicine
Year
2014
Tongue
English
Weight
778 KB
Volume
11
Category
Article
ISSN
1741-0541

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Next-generation sequencing (NGS) is transitioning from being a research tool to being used in routine genetic diagnostics, where a major challenge is distinguishing which of many sequence variants in an individual are truly pathogenic. We describe some limitations of in silico analyses of NGS data t