The therapeutic promise of single enantiomers: introduction
β Scribed by Irving W. Wainer
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 72 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0885-6222
- DOI
- 10.1002/hup.333
No coin nor oath required. For personal study only.
β¦ Synopsis
This review uses several examples drawn from the literature to show how using active enantiomers as therapeutic agents may yield several benefits, including more predictable pharmacokinetics, more accurate drug monitoring and enhanced tolerability. As a result of these benefits, the therapeutic use of single enantiomers will become increasingly important not only in psychopharmacology, but in medicine generally. Indeed, over the early years of the new millennium, the therapeutic use of single active enantiomers is set to redefine the benefit-risk ratio in the management of many common conditions. Copyright 2001 John Wiley & Sons, Ltd.
π SIMILAR VOLUMES
The absolute configuration of an enantiomer of the title compound, (Β±)-1β fumaric acid salt, was determined by X-ray crystallographic analysis of (+)-1 [salt of (+)-tartaric acid [(+)-2]]. This salt for X-ray crystallographic analysis was prepared by a simple method. The analysis of (+)-1 [salt of (+