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The therapeutic potential of the proteasome in leukaemia

โœ Scribed by Scott Marshall McCloskey; Mary Frances McMullin; Brian Walker; Alexandra E Irvine

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
198 KB
Volume
26
Category
Article
ISSN
0278-0232

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โœฆ Synopsis

Abstract

Many cellular processes converge on the proteasome, and its key regulatory role is increasingly being recognized. Proteasome inhibition allows the manipulation of many cellular pathways including apoptotic and cell cycle mechanisms. The proteasome inhibitor bortezomib has enhanced responses in newly diagnosed patients with myeloma and provides a new line of therapy in relapsed and refractory patients. Malignant cells are more sensitive to proteasome inhibition than normal haematopoietic cells. Proteasome inhibition enhances many conventional therapies and its role in leukaemia is promising. Copyright ยฉ 2008 John Wiley & Sons, Ltd.

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