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The Therapeutic Effect of Heme Oxygenase-1 in the Indomethacin-Induced Intestinal Injury in Mice

✍ Scribed by Yoriki, Hiroyuki ;Naito, Yuji ;Takagi, Tomohisa ;Harusato, Akihito ;Yamada, Shinya ;Tsuji, Toshifumi ;Kugai, Munehiro ;Horie, Ryusuke ;Inoue, Ken ;Fukumoto, Kohei ;Yoshida, Naohisa ;Uchiyama, Kazuhiko ;Handa, Osamu ;Yagi, Nobuaki ;Kokura, Satoshi ;Minamiyama, Yukiko ;Ichikawa, Hiroshi ;Yoshikawa, Toshikazu

Book ID
122155330
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
37 KB
Volume
140
Category
Article
ISSN
0016-5085

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## Abstract Sulforaphane is known to be an indirect antioxidant that acts by inducing NF‐E2‐related factor 2 (Nrf2)‐dependent phase II enzymes. In the present study, we investigated the effect of sulforaphane on the expression of heme oxygenase‐1 (HO‐1) in human intestinal Int 407 cells. RT‐PCR and