✦ LIBER ✦

The theoretical and empirical case for in vitro developmental toxicity screens, and potential applications

✍ Scribed by Daston, George P.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 726 KB
Volume: 53
Category: Article
ISSN: 0040-3709
DOI: 10.1002/(sici)1096-9926(199606)53:6<339::aid-tera4>3.0.co;2-v

No coin nor oath required. For personal study only.

✦ Synopsis

In vitro assays for the screening of developmental toxicity potential have been under development for approximately 15 years.

During that period, we have learned that assays consisting of primary cultures of embryonic tissues or cells, intact embryos in culture, or free-living embryos are capable of distinguishing between mammalian developmental toxicants and nondevelopmental toxicants with an accuracy of 280%.

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