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The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system

✍ Scribed by Eliza Wiercinska; Hildegonda P. H. Naber; Evangelia Pardali; Gabri van der Pluijm; Hans van Dam; Peter ten Dijke

Publisher
Springer US
Year
2010
Tongue
English
Weight
640 KB
Volume
128
Category
Article
ISSN
0167-6806

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TGF-beta strongly promotes local tumor progression in advanced epithelial tumors, though the underlying mechanisms are poorly understood. In the present study, we demonstrate the potential of TGF-beta to increase the invasiveness of the pancreatic cancer cell lines PANC-1 and IMIM-PC1. TGF-beta-indu