The TGF-β family and its composite receptors
✍ Scribed by Joan Massagué; Liliana Attisano; Jeffrey L. Wrana
- Book ID
- 113407339
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 852 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0962-8924
No coin nor oath required. For personal study only.
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## Abstract The nature and role of cell surface proteins that bind members of the TGF‐β family has been investigated. TGF‐β, activins, and BMPs each bind to receptors of 55 kDa (type I) and 70 kDa (type II). In the TGF‐β system, these receptors are implicated in the mediation of multiple responses.
## Abstract Transforming growth factor‐β (TGF‐β) responsiveness in cultured cells can be modulated by TGF‐β partitioning between lipid raft/caveolae‐ and clathrin‐mediated endocytosis pathways. The TβR‐II/TβR‐I binding ratio of TGF‐β on the cell surface has recently been found to be a signal that c