Polytherapy with hERG-blocking antiepile
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Christian Danielsson; Faranak Azarbayjani; Anna-Carin Sköld; Niklas Sjögren; Ben
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Article
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2007
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John Wiley and Sons
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English
⚖ 247 KB
## Abstract **BACKGROUND:** The antiepileptic drugs (AEDs) phenytoin, phenobarbital, dimethadione, and carbamazepine cause a similar pattern of malformations in humans, with an increased risk after polytherapy. The teratogenicity has been linked to cardiac rhythm disturbances and hypoxic damage as