The Temporal Relationship between Protein Phosphatase, ICE/CED-3 Proteases, Intracellular Acidification, and DNA Fragmentation in Apoptosis

Temporal relationships between de novo p

Temporal relationships between de novo protein synthesis, calpain and caspase 3-like protease activation, and DNA fragmentation during apoptosis in septo-hippocampal cultures

✍ Brian R. Pike; Xiurong Zhao; Jennifer K. Newcomb; Kevin K.W. Wang; Rand M. Posma 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 460 KB

Caspase 3-like proteases are key executioners in mammalian apoptosis, and the calpain family of cysteine proteases has also been implicated as an effector of the apoptotic cascade. However, the influence of upstream events on calpain/caspase activation and the role of calpain/caspase activation on s