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The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

✍ Scribed by Pullen, Ann M.; Marrack, Philippa; Kappler, John W.

Book ID
109756812
Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
737 KB
Volume
335
Category
Article
ISSN
0028-0836

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## Abstract T lymphocytes recognize antigens in the form of peptides presented by major histocompatibility complex (MHC) molecules on the cell surface. Only a small proportion of MHC class I and class II molecules are loaded with foreign antigenic peptides; the vast majority are loaded with thousan