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The T Cell Protein Tyrosine Phosphatase Is a Negative Regulator of Janus Family Kinases 1 and 3

✍ Scribed by Paul D. Simoncic; Ailsa Lee-Loy; Dwayne L. Barber; Michel L. Tremblay; C.Jane McGlade

Book ID: 114319031
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 321 KB
Volume: 12
Category: Article
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(02)00697-8

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## Abstract ## Objective Mitogen‐activated protein kinases (MAPKs) are activated by proinflammatory stimuli. MAPK phosphatases (MKPs), in particular MKP‐1, have been identified as endogenous negative regulators of MAPK activation. Since MAPKs are known to be important in rheumatoid arthritis (RA)