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The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation

✍ Scribed by Ranit Kedmi; Noa Ben-Arie; Dan Peer


Book ID
108070113
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
443 KB
Volume
31
Category
Article
ISSN
0142-9612

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## Abstract Microglia are activated by lipopolysaccharide (LPS) to produce neurotoxic pro‐inflammatory factors and reactive oxygen species (ROS). While a multitude of LPS receptors and corresponding pathways have been identified, the detailed mechanisms mediating the microglial response to LPS are