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The Synthetic Versatility of Alkoxycarbonyl- and Hydroxymethyl-piperazine-2,5-diones.

โœ Scribed by Christina L. L. Chai; John A. Elix; Paul B. Huleatt


Publisher
John Wiley and Sons
Year
2005
Weight
24 KB
Volume
36
Category
Article
ISSN
0931-7597

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โœ Christina L.L. Chai; John A. Elix; Paul B. Huleatt ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 135 KB

Mild methods for controlled C-and N-alkylation of 3-benzyloxycarbonylpiperazine-2,5-diones are reported. The benzyloxylcarbonyl substituent can also serve as latent functionality for N-acyliminium ion formation and subsequent trapping enables installation of new carbon and/or heteroatom substituents