Withanolide is a new series of naturally occuring ., Among those, withaferin A (1)" has been paid a special inhibitory activity. Structural features of 1 are the C28 steroidal lactones
The synthesis of the rings A/B in withaferin A and other withanolides
โ Scribed by M. Weissenberg; E. Glotter; D. Lavie
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- French
- Weight
- 212 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
A recent comication on the synthesis of the A/B rings moiety of withaferin Al, prompted us to report our own approach to this probslm which is markedly different, and led to the successful preparation of the title derivatives. This study follows a detailed chemical investigation performed earlier in our laboratory' on the isolation and characteri-(6-B t), 5.99 (2-H, dd, ~110 and < 1 Hz), 4.64 (4-H, dd, J=4.5 and < 1 Hz), 1.45 (19-H, s) In partial fulfillment of the reguirements for the Ph.D. degree of M.
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