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The synthesis of substituted pyridylpyrimidine fungicides using palladium-catalysed cross-coupling reactions

โœ Scribed by Stephanie L Hargreaves; Brian L Pilkington; Sally E Russell; Paul A Worthington


Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
118 KB
Volume
41
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


Various substituted phenyl, pyridyl and benzyl zinc chlorides have been generated from the corresponding lithium or magnesium organometallic reagents. These have been cross-coupled with 2-(6-bromo-2pyridyl)pyrimidines in the presence of tetrakis(triphenylphosphine)palladium(0) to produce a series of substituted pyridylpyrimidine fungicides in 32-99% yields.


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