The synthesis of substituted pyridylpyrimidine fungicides using palladium-catalysed cross-coupling reactions
โ Scribed by Stephanie L Hargreaves; Brian L Pilkington; Sally E Russell; Paul A Worthington
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 118 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Various substituted phenyl, pyridyl and benzyl zinc chlorides have been generated from the corresponding lithium or magnesium organometallic reagents. These have been cross-coupled with 2-(6-bromo-2pyridyl)pyrimidines in the presence of tetrakis(triphenylphosphine)palladium(0) to produce a series of substituted pyridylpyrimidine fungicides in 32-99% yields.
๐ SIMILAR VOLUMES
A series of novel functionalized trisulfonated phthalocyanines were prepared in good to excellent yield using the monoiodo trisulfonated phthalocyanine as precursor for palladium-catalysed cross coupling reactions (Heck reaction and Buchwald amination).
Here is described a high yield synthesis of 3-substituted 4H-1,4-benzoxazines via palladium-catalysed coupling reactions between organostannanes and a vinylphosphate obtained from a benzoxazin-3-one derivative.