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The synthesis of substituted phenylpyrimidines via suzuki coupling reactions

✍ Scribed by Thomas J. Delia; Jennifer M. Schomaker; Alvin S. Kalinda


Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
65 KB
Volume
43
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

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This paper describes the mon‐, di‐, and triarylation of the pyrimidine ring. It is possible to introduce one or more aryl rings in generally good yields and in a specific order, namely first in position 4, second in position 6, followed by position 2. A study of solvent and catalyst requirements has also been conducted.


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## Abstract magnified image A facile and convenient method for the synthesis of highly functionalized 2‐(substitutedbiphenyl) based benzimidazoles has been reported by the application of Suzuki‐Miyaura cross coupling reaction.