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The Synthesis of Some New Cysteine-Containing Unsymmetrical Disulfides

โœ Scribed by Harpp, David; Back, Thomas


Book ID
118055845
Publisher
American Chemical Society
Year
1971
Tongue
English
Weight
289 KB
Volume
36
Category
Article
ISSN
0022-3263

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meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesiz