The synthesis of phospholipids by direct amination

✍ Scribed by Hansjörg Eibl; Alfar Nicksch

• Book ID: 103042006
• Publisher: Elsevier Science
• Year: 1978
• Tongue: English
• Weight: 415 KB
• Volume: 22
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(78)90002-6

✦ Synopsis

The bromoethylesters of phosphatidic acids and their analogues are general intermediates in the synthesis of phosphollpids. A direct amination with different amines such as ammonia, methylamine, dimethylamine and trimethylamine results in the corresponding phosphatidylethanolamines and -cholines. In addition to the well elaborated reactions of bromoethylesters with trimethylamine and dimethylamine, the synthesis of phosphatidylethanolamines and -(N-methyl)-ethanolamines by amina~ion with ammonia and methylamine is now possible in high yields (> 90%) without the need of the usual protecling groups.