The synthesis of peptides in aqueous medium, IV. A novel protecting group for cysteine
β Scribed by Daniel F. Veber; John D. Milkowski; Robert G. Denkewalter; Ralph Hirschmann
- Publisher
- Elsevier Science
- Year
- 1968
- Tongue
- French
- Weight
- 123 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0040-4039
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## Abstract We have found a novel way of protecting the hydroxyl function in hydroxyβLβamino acids, making use of the tβbutoxy group, which is readily split by acids, but not by bases. This group is introduced by acidβcatalysed addition of isobutene to Nβacylated hydroxyβLβamino acids. The blockin
In this communication we introduce a promising masking agent --the vinyloxycarbonyl or VOC group --for the protection of amino functions in peptide chemistry. Amino acids are easily converted to their N-VOC derivatives (l\_) in dilute aqueous base using the known vinyl chloroformate' in dioxane as t