A series of chiral alkylphosphonates bearing b-stereogenic center were synthesized in good enantioselectivities (up to 95% ee) via the CuH-catalyzed asymmetric conjugate reduction of b-substituted a,b-unsaturated phosphonates under optimal conditions using Cu(OAc) 2 ÁH 2 O as the copper source, (R)-
✦ LIBER ✦
The synthesis of optically active building blocks carrying an α, α-dihalogeno-β, β, β-trifluoroethyl group
✍ Scribed by Tomoya Kitazume; Takeshi Ohnogi; Jenq Tain Lin; Takashi Yamazaki; Keizo Ito
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 499 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-1139
No coin nor oath required. For personal study only.
✦ Synopsis
Optically active molecules with a.a-dihalogeno-8,8.atrifluoroethyl groups were prepared by the microbial hydrolysis of the corresponding esters.
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## Abstract Reductive alkylation of diselenides based on Weinreb amides is followed by coupling with Grignard reagents to produce the title compounds including glycosyl derivatives.