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The synthesis of novel macrocyclic multidentate compounds from dioxodioic acids

✍ Scribed by R. E. Asay; J. S. Bradshaw; S. F. Nielsen; M. D. Thompson; J. W. Snow; D. R. K. Masihdas; R. M. Izatt; J. J. Christensen


Book ID
112123964
Publisher
Journal of Heterocyclic Chemistry
Year
1977
Tongue
English
Weight
400 KB
Volume
14
Category
Article
ISSN
0022-152X

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Two macrocyclic peptides 1a and 1b were synthesized directly from e-aminoquinolinecarboxylic acid 2a and 2b, respectively. The preorganization of the uncyclized intermediates mediated by hydrogen bonding assisted the cyclization. The structures of 1a and 1b were characterized by 1 H and 13 C NMR spe