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The synthesis of multiple deuterated N-n-propyl-norapomorphine N-(d7) and derivatives

✍ Scribed by Yigong Gao; Thomas M. Traino; Paul Vouros; John L. Neumeyer

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
264 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

secticm of W i n a l m, college of Fhamacy and W i d m t h Professions*, Department of Chemistrys, Northeastern University, Boston, m 02115 SMmRY NpA has been labelled us-n-prupyl ia3ide(d,) thna@~ alkylatim of noroodeine fdllawed by a miltistep rarte w h i c h also affords the related darterated anal-N-n-prqy-* theprodrug l O , l l ~l & c % y -N P A ( d , ) and lO,ll-+ZPA(+). T. m%mcmm R(-) -N-n-propylnorapmorphine (NPA, 3) bas been thorowhly investigated due t o its potent dopaminergic activity' (Figure 1) . Oonsequently, the potential of the -1 -deriMtive of NPA -A, la) as a prodrug b -thq I%ukhsm's disease and &M n a r r o l o g i o d l ~ is ud=c investigation. Additialally, the -lab33 anal-N+Ppmpy-* (4a)mthe s t u ~~ of patgltial mstabalitas of NPA~. w o r e , stable ( -'oactive) kotzpes sucfi as dabrim amid be used to label these patential -to abtainanalogswhid~warldbe useful far metabolic and 1 0 , 1 1 --W) are of interest in m c etudies ard as true intanral sta&uds for G C -s assays.

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