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The synthesis of enantiomerically pure, symmetrically substituted cyclopropane phosphonic acids — A constrained analog of the GABA antagonist phaclophen

✍ Scribed by Stephen Hanessian; Louis-David Cantin; Stéphan Roy; Daniele Andreotti; Arthur Gomtsyan

Book ID: 104256263
Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 249 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(96)02518-x

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✦ Synopsis

The stereocontrolled conjugate addition of anions derived from chiral ot-chlomphosphonamides to ~[~-unsaturated esters leads to the corresponding 3-chlom ester adducts which undergo intramolecular expulsion of the chlorine atom to give the corresponding cyclopmpanes.

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