The synthesis of codeine and morphine glucoronides
β Scribed by H. Yoshimura; K. Oguri; H. Tsukamoto
- Publisher
- Elsevier Science
- Year
- 1968
- Tongue
- French
- Weight
- 233 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0040-4039
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Objective: The analgesic effect of codeine depends on its O-demethylation to morphine via sparteine oxygenase (CYP2D6) in the liver and presumably also via this enzyme in the CNS. We studied the ability of quinidine, which is a potent inhibitor of CYP2D6, to penetrate the blood brain barrier and its