The Synthesis of Azadirachtin: A Potent Insect Antifeedant
✍ Scribed by Steven V. Ley; Antonio Abad-Somovilla; James C. Anderson; Carles Ayats; Rolf Bänteli; Edith Beckmann; Alistair Boyer; Maria G. Brasca; Abigail Brice; Howard B. Broughton; Brenda J. Burke; Ed Cleator; Donald Craig; Alastair A. Denholm; Ross M. Denton; Thomas Durand-Reville; Luca B. Gobbi; Michael Göbel; Brian Lawrence Gray; Robert B. Grossmann; Claire E. Gutteridge; Norbert Hahn; Sarah L. Harding; David C. Jennens; Lynn Jennens; Peter J. Lovell; Helen J. Lovell; Mary L. de la Puente; Hartmuth C. Kolb; Win-Jan Koot; Sarah L. Maslen; Catherine F. McCusker; Amos Mattes; Andrew R. Pape; Andrea Pinto; Dinos Santafianos; James S. Scott; Stephen C. Smith; Andrew Q. Somers; Christopher D. Spilling; Frank Stelzer; Peter L. Toogood; Richard M. Turner; Gemma E. Veitch; Anthony Wood; Cornelia Zumbrunn
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 596 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0947-6539
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## Abstract For Abstract see ChemInform Abstract in Full Text.
Synthesis of Insect Antifeedants Related to Azadiradione. -The key step in the synthesis of title compound (IX) are a Nazarov cyclization of the divinyl ketone (IV) with acid and a dyotropic rearrangement of the epoxide (VII). The overall yield of the 8-step reaction is 18%. -(FERNANDEZ MA-
Investigations of the antifeedant mode of action of azadirachtin and four synthetic analogues, 22,23-dihydroazadirachtin, 3-tigloylazadirachtol, 11methoxydihydroazadirachtin and 22,23-bromoethoxydihydroazadirachtin have revealed that both polyphagous and oligophagous insects are behaviourally respon