✦ LIBER ✦

The synthesis of an ATP-γ-Peptidyl ester as a potential probe of c-AMP-dependent protein kinases

✍ Scribed by Pamela R. Lashmet; Kuo-Chang Tang; James K. Coward

Publisher: Elsevier Science
Year: 1983
Tongue: French
Weight: 247 KB
Volume: 24
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)86381-9

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✦ Synopsis

The synthesis of a y-dipeptidyl ester of ATP has been effected by coupling a phosphopeptide (e.g. N-acetylalanyl-0-(phosphoryl)serine methyl ester) to ADP in the presence of l,l'carbonyldiimidazole. Compounds of this type, containing longer peptides, are proposed as potential multisubstrate adduct inhibitors of c-AMP-dependent protein kinases.