The sulfuric acid-promoted reaction of benzo-15-crown-5 O) and benzo-18-crown-6 (6) with aliphatic aldehydes, leading to the formation of anthracene crown et~rs, was studied. A substantial substiment effect on the reaction comse was found. For the isdmtyi group the highest yield was obtained, while
The synthesis of adrenaline crown ethers
โ Scribed by Fenton, David E.; Parkin, Donald; Newton, Roger F.
- Book ID
- 119968425
- Publisher
- Royal Society of Chemistry
- Year
- 1981
- Weight
- 804 KB
- Category
- Article
- ISSN
- 1472-7781
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๐ SIMILAR VOLUMES
Che synthesis and chemistry of macrocyclic polyethers are currently receiving a great deal of attention. Very recently Cram and co-workers 132 have reported the synthesis of two crown ethers (3,~ and QJ). We have prepared two series of novel crown ethers in which respectively, the 1,3and 2,5-positio
The Synthesis of Anthracene Crown Ethers Derived from Benzo-Crown Ethers. -A method to obtain anthracene crown ethers starting from benzo-15-crown-5-ether and benzo-18-crown-6-ether and various aldehydes is described. The yield strictly depends on the aldehyde. Cyclohexanone leads to a new class of
3-Phenyl-and 3-(p-methoxyphenyl)-7,8-dihydroxy and -6,7-dihydroxychromenones were prepared from ethyl 3-oxo-2-phenylpropanoate, ethyl 3-oxo-2-(4-methoxyphenyl)-propanoate and the trihydroxy benzenes in H 2 SO 4 . 3-Aryl-7,8-and3-aryl-6,7-dihydroxy-2H-chromenones reacted with the bis-dihalides of pol