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The synthesis of acetyl-CoA byClostridium thermoaceticumfrom carbon dioxide, hydrogen, coenzyme A and methyltetrahydrofolate

✍ Scribed by Ewa Pezacka; Harland G. Wood

Publisher: Springer
Year: 1984
Tongue: English
Weight: 781 KB
Volume: 137
Category: Article
ISSN: 0302-8933
DOI: 10.1007/bf00425809

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✦ Synopsis

It has been demonstrated that enzymes from

Clostridium thermoaceticum catalyze the following reaction in which Fd is ferredoxin and CHJHF is methyltetrahydrofolate.

CO2 + H2 + CH3THF + CoASH A~P,W> CH 3 COSCoA + THF + H20.

The system involves hydrogenase, CO dehydrogenase, a methyltransferase, a corrinoid enzyme and other unknown components. Hydrogenase catalyzes the reduction of ferredoxin by H2; CO dehydrogenase then uses the reduced ferredoxin to reduce CO2 to a one-carbon intermediate that combines with CoASH and with a methyl group originating from CH3THF to form acetyl-CoA. It is proposed that these reactions are part of the mechanism which enables certain acetogenic autotrophic bacteria to grow on CO2 and H z.

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