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The synthesis of 4H-pyrrolo[2,1-c] [1,4] benzoxazine

✍ Scribed by Marino Artico; Giulio Cesare Porretta; Giovanni De Martino


Book ID
112122396
Publisher
Journal of Heterocyclic Chemistry
Year
1971
Tongue
English
Weight
256 KB
Volume
8
Category
Article
ISSN
0022-152X

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A convenient synthesis of pyrrolo[2,1-c]
✍ Isabel SΓ‘nchez; Maria Dolors Pujol πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 417 KB

The pyrrolo [2,l-c][1,4]benzoxazine system was synthesized from 2-fluoroaniline involving an intramolecular nucleophilic displacement of the fluoride atom. The intermediate alcohols 7a and 10 were treated in basic media under strictly controlled conditions which led to the desired tricyclic structur