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The synthesis of 4,5-benzohomotropone

✍ Scribed by Yukio Sugimura; Nobuo Soma; Yukichi Kishida


Book ID
104247296
Publisher
Elsevier Science
Year
1971
Tongue
French
Weight
210 KB
Volume
12
Category
Article
ISSN
0040-4039

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## Abstract 3‐Hydroxypropionitrile was subjected to a base‐catalyzed exchange reaction in D~2~O which provided 2,2‐dideuterio‐3‐deuteroxypropionitrile (DOCH~2~CD~2~CN) in 70% yield. Reduction of the nitrile with LiAlD~4~ gave 3‐amino‐2,2,3,3‐tetradeuteriopropan‐1‐o1 (HOCH~2~CD~2~CD~2~NH~2~) in a cr