The Synthesis of 3-Substituted Derivatives of Methylcholanthrene
โ Scribed by Fieser, Louis F.; Riegel, Byron
- Book ID
- 120167196
- Publisher
- American Chemical Society
- Year
- 1937
- Tongue
- English
- Weight
- 546 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
A novel synthesis of 3-methylcholanthrene is described which is operationally simpler than the method in current use and is potentially applicable to the synthesis of a wide range of other polycyclic hydrocarbons and their oxidized carcinogenic metabolites.
Despite well-developed methodology for the carbon-carbon bond formation at C-l position in isoquinoline skeleton (e.g., Reissert reaction'), there is no comparable procedure for the introduction of an alkyl group at C-3 position in dihydroisocarbostyril derivatives. We have recently developed a nove