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The synthesis of 3-amidinio-2-aminopyridine-4-carboxylates

✍ Scribed by Oleg E. Nasakin; Vladimir P. Sheverdov; Inna V. Moiseeva; Anatoli N. Lyschikov; Oleg V. Ershov; Vladimir N. Nesterov

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
101 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new class of isonicotinic acid derivatives, 3-amidinio-2-aminopyridine-4-carboxylates, from aqueous ammonia and ~,~,y,y-tetracyanoalkanones, is reported.

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✍ Chuansheng Niu; Jun Li; Terrence W. Doyle; Shu-Hui Chen πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 603 KB

Palladium-catalyzed cross-coupling of methylboronic acid with 2-chloro-3-nitropyridine produced 2methyl-3-nitropyridine 4 in one step in high yield. Oxidation of 4 with selenium dioxide gave aldehyde 5. Alternatively, condensation of 4 with DMFDMA followed by oxidation gave 5 in a two step higher yi