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The synthesis of 2′-homouridine, its incorporation into a dinucleoside monophosphate and hydrolytic behaviour of the dimer

✍ Scribed by John B.J. Pavey; Anthony J. Lawrence; Andrew J. Potter; Richard Cosstick; Ian A. O'Neil

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 273 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01478-6

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✦ Synopsis

An efficient route to 2'-homouridine (1), a new nucleoside analogue, is reported that is based on an ene reaction. This nucleoside has been incorporated into a dinucleoside monophosphate and hydrolytic studies on the dimer show that it does not behave like a ribonucleotide.

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