Ethyl 1,2,4-triazine-5-carboxylates 6 were prepared by heating N,N-dimethylaminomethyleneor ethoxymethylenehydrazones 5 with ammonium acetate in acetic acid at-100ยฐC. NMR-studies confirmed the absence of their regio isomers (6-carboxylates), showing the high regioselectivity of this procedure. Rece
โฆ LIBER โฆ
The Synthesis of 1,2,4-Triazine
โ Scribed by Paudler, William W.; Barton, Jerry M.
- Book ID
- 120607294
- Publisher
- American Chemical Society
- Year
- 1966
- Tongue
- English
- Weight
- 385 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-3263
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To develop nonacidic, nonsteroidal anti-inflammatory agents without GI complications, a series of asymmetric triazines was synthesized and evaluated for anti-inflammatory efficacy in the carrageenan-induced pedal edema assay. Toxicity was estimated by determination of approximate LD50 values in mice